Cytotoxicity of Contrast Media Iohexol on IL-1beta stimulated Bovine Chondrocytes
نویسندگان
چکیده
منابع مشابه
Effect of hydrostatic pressure of various magnitudes on osteoarthritic chondrocytes exposed to IL-1beta.
BACKGROUND & OBJECTIVES Several in vitro studies have shown the importance of mechanical compression or hydrostatic pressure (HP) as a modulator of cartilage metabolism. The present study was undertaken to evaluate the in vitro effects of cyclical low HP (1-5 MPa) and continuous high HP (24 MPa) applied in the presence or absence of interleukin (IL)-1beta on human osteoarthritis (OA) chondrocyt...
متن کاملEarly response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta
Recent work has established that IL-1beta plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and osteoarthritis. These processes result from the ability of this inflammatory cytokine to activate expression of genes for neutral proteases, such as the matrix metalloproteinases. While IL-1beta activates matrix metalloproteinase genes wi...
متن کاملModulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.
OBJECTIVE The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes. The transforming growth factor-beta (TGF-beta) family of growth factors generally exerts an anabolic or repair response; in contrast, proinflammatory cytokines such as interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-al...
متن کاملEffects of stanozolol on normal and IL-1β-stimulated equine chondrocytes in vitro
BACKGROUND Intra-articular administration of stanozolol has shown promising results by improving the clinical management of lameness associated with naturally-occurring osteoarthritis (OA) in horses, and by decreasing osteophyte formation and subchondral bone reaction in sheep following surgically induced OA. However, there is limited evidence on the anti-inflammatory and modulatory properties ...
متن کاملCytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta
INTRODUCTION Although IL-1β is believed to be crucial in the pathogenesis of osteoarthritis (OA), the IL-1β blockade brings no therapeutic benefit in human OA and results in OA aggravation in several animal models. We explored the role of a cytokine signaling 1 (SOCS1) suppressor as a regulatory modulator of IL-1β signaling in chondrocytes. METHODS Cartilage samples were obtained from patient...
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ژورنال
عنوان ژورنال: Journal of the Hellenic Veterinary Medical Society
سال: 2018
ISSN: 2585-3724,1792-2720
DOI: 10.12681/jhvms.16394